It is particularly useful for older couples because the share of chromosomal aberrations rises exponentially with both paternal and maternal age. The share of eggs with extra chromosome or chromosomes rises from 20% of aberrant eggs at 30 years old to 80% at the age of 40.
The couples with a history of miscarriage;
The couples with unsuccessful IVF;
The couples with a family history of the heritable disease;
The history of chromosomal pathology or other genomic abnormalities;
One or both parents have adverse genetic mutations or chromosomal aberration.
Fill in your contact form and details about your case. Our experts will answer all your questions concerning Preimplantation Genetic Testing.
Today several different kinds of PGS and PGD are available:
Preimplantation Genetic Testing for Aneuploidies (PGT-A or pgs genetic testing) previously known as Preimplantation Genetic screening is a method dedicated to ensure that that embrio have proper number of chromosomes, a building blocks of our genetic material consisting mainly from DNA, which is important to producing healthy child.
The embryos, which have an abnormal number of chromosomes called aneuploid are extremely unlikely (0-10%) to result in successful pregnancy. Also it can lead to lifelong intellectual disability (trisomy of 21 chromosome also known as Down syndrome), aberrations of normal sexual development (Turner syndrome) or Lou Gehrig’s disease, which manifests in progressing muscular dystrophy.
Inasmuch Preimplantation Genetic Testing for Aneuploidies identify and eliminate those embios it increases the chances for successful pregnancy especially in older couples and those with inherited burden of genetic pathologies. For example for average 43 year old mother it reduces the chances for miscarriage by two times from 42 to 19%.
Also it allows the use of single embryo transfer and thus reduces the risks of multiple gestation birth, which can be dangerous for mother and child.
It is helpful in family planning, because it can help to find out if there are enough healthy frozen embryos or additional cycles of IVF is needed to ensure prefered number of kids.
To sum up, it alleviates financial burden, reduces the risks for mother and child, and saves money.
Preimplantation Genetic Testing for Chromosomal Structural Rearrangements (PGT-SR) - Just like PGT-A this method helps to increase the chances for successful pregnancy and healthy child.
It allows us to ensure that embryos' chromosomes (building blocks of genetic material) are correctly arranged and have proper size. The embryos with unbalanced Chromosomal Structural Rearrangements are unlikely to produce healthy offspring also it can lead to heavy burden of disease including Down syndrome.
Those mutations can form de-novo or exist in parents. 1 in 500 people carry Chromosomal Structural Rearrangements without knowing about it.
Preimplantation Genetic Testing for Monogenic/Single-Gene Disorders (PGT-M) - is a method looking for relatively small genetic mutations. But do not let the size trick you. Those mutations can lead to serious diseases like Huntington’s disease, which is a mutation that manifests in cognitive decline and uncontrollable movements or family hypercholesterolemia which results in cardiovascular diseases, sickle cell, which can result in severe anemia and chronic pain syndrome and musc. This method is particularly useful for couples with family history of hereditary disease or those who come from populations with high prevalence of genetic disease.
Preimplantation Genetic Testing - Whole Genome Sequencing
In “Create U Future” we use state of art technology called NGS (next generation sequencing), which allows us to achieve unprecedented precision and speed of analysis. Unlike other companies we are able to analyze not only several genes, but the whole genome, all genes which have been reliably linked to important conditions. This means that even if the disease has been discovered only recently and no commercial test is available yet we are still ready to detect it. However this technology can give you much more than just disease prevention. It will give you hints for a healthy diet for your particular child, based on individual features of metabolism, taste perception, and predisposition to intolerance of certain nutrients such as lactose and gluten. You will know about potential talents of your future child in certain types of competitive sports, risks of sports trauma, drugs that will be most effective for your child, and what will bear increased risk of adverse effects.
A full genome study is the best investment, which will give your child lifetime access to up-to-date information about his or her health for decades to come.
Bringing a child to this world is one of the most serious and lasting decisions in human life.
The proper outcome of IVF with Preimplantation Genetic Testing largely depends on expertise of fertility specialists, geneticists, strict adherence to the protocols and guidelines at all stages. At “Create U future” we carefully control all of those factors to ensure the best possible chances of successful delivery.
In “Create U future” we believe that every case is different. From the very beginning we work with you to find the best treatment plan for your particular case, surround you with care covering all issues from insurance and financial support, to thorough diagnosis.
Our company provides a full spectrum of services specially tailored for single men who want to become a father. We provide “three way parenting services”, where the surrogacy mother provide gestation and contract mother provides an egg, helps with the selection of personnel for child care, draws up educational and training programs, implements and monitors their implementation, and the man receives full custody of the child, a reliable guarantee of his parenthood.
Our base of contract mothers includes leading scientists, elite models, female athletes, and graduates of the world's leading universities.
“Create U Future” 24/7 complex team delivers complex all inclusive programm, we are able to be with our clients on all stages from donor search and legal issues to maternity services, guarantee the adherence to modern protocols at all stages of the procedure. By providing access to the best professionals and international standards of practice, we save your time, money and protect the health of the future mother and child.
Although the effectiveness of all reproductive techniques is indeed lowering with age of the spouse, modern techniques give chance to patients even after menopause.
The process of PGS and PGD are part of ivf preimplantation genetic diagnosis, which consist of 8 steps.
Book a zoom call and send all of your test results so our professionals will develop your personalized treatment plan.To make sure that IVF with donor eggs is the best option for the client, our staff make in depth analysis of the patient's medical history, fertility testing and more.
From the very first meeting we are eager to find the best treatment plan for your particular case, to offer care covering all issues from insurance and financial plans, to thorough diagnosis.
Ensuring the best possible results for future mother and child may require lifestyle changes. “Create u Future” provides consultations with nutriciologists, physical therapy specialists that will help you to have a safer journey through pregnancy.
Personally optimized hormonal stimulation of superovulation is used on this stage. To create it our fertility specialist analyzes the hormone levels in blood and ultrasound finding on the ovaries. As a result several oocytes become mature at the same time. This process takes 1,5-2 weeks.
This almost painless procedure is done through as little as 30 minutes and mild anesthesia will be used. According to our statistic most patients successfully return to work the next day after procedure experiencing only minor side effects or no side effects at all.
The eggs are fertilized by the spermatozoa of the future father. Embryo transfer is an easy procedure that does not require anesthesia. The patient is additionally prescribed progesterone medications to ensure a successful start of the pregnancy. Create U Future also provides the opportunity to choose the gender of chosen embryos, and save unused embryos for later storage.
One or two cells are extracted from each embryo and thoroughly analyzed
Healthiest embrio(s) are selected for the embryo transfer or cryopreserved for later use.
Create U Future provide wide range of maternity services to ensure successful pregnancy resolution.
The goal of PGS is to increase the likelihood that the selected embryo(s) will result in a healthy conception for your future family. PGS testing reduces the risk of miscarriage, decreases the time it takes to become pregnant, and reduces the need to transfer multiple embryos. Although PGS often incurs additional costs, it can reduce the cost of your IVF journey in the long run by reducing the number of transfers needed to conceive.
PGS/PGT-A Also known as "family balancing" or "family planning. PGS/PGT-A can be used to determine the sex chromosomes of each embryo and transfer the embryo(s) of the desired sex. Reasons for sex selection may be as follows:
We believe Every expectant parent faces different circumstances, and choosing the sex of your child is a deeply personal reason. Your fertility clinic will discuss this in more detail in connection with your unique scenario and ways to respect your decision.
By performing PGS/PGT-A on viable embryos, your fertility doctor can select chromosomally normal embryos and rule out those that might interfere with a healthy birth, even if they look quality before screening. Preimplantation genetic diagnosis procedure (PGD) allows to ensure healthy pregnancy even if one or both intended parents have a known genetic condition, such as cystic fibrosis.
PGS & PGD genetic testing gives fertility doctors an idea of which embryos will have the best chance of implantation and healthy development. If your embryos have certain abnormalities that prevent implantation in the uterus or early embryo development, your doctor can identify and refrain from transferring such embryos to optimize the IVF process. However, some chromosomal abnormalities are less dangerous for the embryo and allow it to implant. They can still interfere with the proper development of the pregnancy and lead to pregnancy loss or birth after embryo transfer.
In fact, taking the cost of preimplantation genetic testing (pgt) helps you to save money due to the reduced number of needed Ivf cycles.
By using PGS and PGD, your fertility clinic can avoid failed embryo transfers by transferring the healthiest embryos first. Understanding which embryos will help you achieve a full-term pregnancy will allow you to avoid wasting months transferring embryos that will not result in a successful pregnancy and birth.
PGS testing sometimes requires additional costs, depending on your provider and payment options. Nevertheless, this procedure gives you an indication of which embryos are worth transferring and freezing. Even though there are additional costs for PGS and PGD, understanding which embryos are suitable for storage and which embryos are worth transferring during IVF provides long-term benefits.
A significant benefit of PGS/PGT-A is the reduced uncertainty that patients may experience before and after embryo transfer. PGS allows for a guaranteed healthy embryo, reduces the risk of pregnancy loss, genetic disorders and reduces emotional stress, especially for patients who have previously experienced an unfortunate loss in the form of a miscarriage.
When undergoing PGS, you should be prepared for the possibility that the embryos may be genetically defective, which means that your fertility doctor may not be able to transfer them into your uterus. As heartbreaking as it is, your doctors will tell you the best course of action and get you back on the path to successful, healthy conception and pregnancy.
In vitro fertilization with PGD and PGS may look like additional expenses. It is not a surprise because IVF itself is a long and expensive procedure, especially if you are using a gestational carrier (or surrogate) to carry the baby. However due to the increased success rate IVF with PGD and PGS can actually save your time and money. It is especially true for older couples because when we get older the speed of losing ovarian reserve, the number of aberrant oocities increase exponentially. It needs to be noted that pgs testing cost depends on many factors including the number of embryos to be analyzed. Contact us to know preimplantation genetic screening cost or preimplantation genetic diagnosis cost in your particular case. Our counselors are available 24/7
Fertility journey is a rocky one - you can outbid the odds, but there are no guarantees about the outcome. There is still a small chance that embryos selected with PGS and PGD will not result in a pregnancy, and it depends on other factors, such as the fertility clinic. Talk to your fertility doctor to find out about the prognosed rates and results in your particular case.
For patients over the age of 37, PGT-A can increase the rate of pregnancy. However, for women younger than 37, the method cannot increase the chances of conception. On the flip side, for women younger than 37 it still can increase the chances to conceive a healthy child, which is especially important for patients with a family history of hereditary disease.